| Prof. Dr. Martin
Fromm Institut für Experimentelle und Klinische Pharmakologie und Toxikologie Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie Emil-Fischer-Zentrum Friedrich-Alexander-Universität Erlangen-Nürnberg Fahrstr. 17 91054 Erlangen ph. +49 (0)9131 85-22772 FAX +49 (0)9131 85-22773 martin.fromm@pharmakologie.med.uni-erlangen.de http://www.pharmakologie.uni-erlangen.de/ |
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Research areas:
In spite of the correct use of drugs, a significant proportion
of
the patients has no adequate drug effect or suffers from drug toxicity.
This variability in drug effects can be due to genetic or environmental
(e.g. nutrition, comedication) factors. The goal of our group is to
help to get a better understanding of the causes for interindividual
differences in drug effects and to further optimize drug treatment.
It is now well established that many drugs are translocated through
cell membranes via different transporter proteins. In addition to drug
transport, metabolism is also an important determinant of drug
disposition and effects. Our research focusses on the following topics:
- Drug transporter (OATPs, OCTs, BCRP, P-glycoprotein, MRPs)
- Intestinal and hepatic drug metabolism
- Pharmacogenomics